Pharma, Pharmaceutics and Biotechnology Conference

Pharmacokinetics is the study of the temporal changes occurring in the concentration of drugs in body systems and such knowledge is relevant to understanding how drugs influence pharmacological and toxicological effects in a patient.

Of course, a good part of this session will be focused on the ADME process, that is, absorption, distribution, metabolism, and excretion. During the absorption stage of drug introduction into the body, it indicates the manner by which a drug is absorbed into the bloodstream. Different variables such as drug formulation, route of administration, and effect of food all contribute toward changing the rates of drug absorption. Critical factors that influence this are thus understood so that drugs can reach as early as possible within the therapeutic levels that can result from optimal delivery.

Once absorbed, drugs are distributed throughout the body by factors such as blood flow, tissue permeability, and protein binding. In this lecture, the volumes of distribution and how this concept applies to pharmacological effects of a drug will be discussed in detail.

To predict how drugs behave in their tissues and possibly interfere with each other, distribution must first be understood. Drug metabolism is a chemical reaction that often primarily occurs in the liver; metabolizing drugs involves chemical modification for easier excretion from the body. One of the common changes produced in this process involves making lipophilic compounds more hydrophilic, thereby more easily eliminated.

The session would include periods of drug metabolism that involve Phase I which includes functionalization, and Phase II that involves conjugation reactions. Lastly, the session would cover the involvement of cytochrome P450 enzymes in drug interactions.

The pharmacokinetics would conclude on excretion, and the kidneys play a huge role in this process.

This session deals with mechanisms of elimination by the kidneys and factors that influence clearance, an important concept to be used in determining dosing regimens to effect therapeutic levels without causing toxicity. It is important to understand the half-life or the time it takes for the concentration of drug in the blood to decrease by 50%.Now, in pharmacokinetic modeling, drug behavior in the body can be predicted and considered in clinical decision-making.

This session outlines several approaches to modeling and how they might be translated into a type of individualized therapy across patient-specific factors of age, weight, renal function, and genetic variation.

Participants will be updated on the latest developments-including population pharmacokinetics and integration of pharmacogenetics into dosing strategies-which enable healthcare professionals to select drugs, dose, and monitor medications optimally for best patient outcomes in consideration with insights from the principles of pharmacokinetics.

During this session, it will be covered totally on pharmacokinetics, while highlighting the role that serves in the development of safe and effective therapeutic regimens; therefore, the participants can deepen their understanding concerning how the application of pharmacokinetic principles could lead to individualized patient care and optimization of therapeutic efficacy.