Pharma, Pharmaceutics and Biotechnology Conference

Drug metabolism is another fundamental aspect in pharmacokinetics that can really affect the efficacy and safety of the therapeutic agents.

This session shall engage with the complexity of biochemical processes that drugs undergo in the body to explore metabolic pathways as well as factors affecting metabolism and their implications for clinical practice.

Drug Metabolism: The biochemical transformations by which drugs are converted into their active or inactive metabolites, mainly in the liver. Most of these play important roles in determining both the bioavailability and the duration of action of the drug. Important metabolic pathways will include Phases I and Phase II: oxidation, reduction and hydrolysis; conjugation.

This further discussion will include the role of cytochrome P450 enzymes in drug metabolism. Factors Influencing Drug Metabolism There are so many factors that may influence drug metabolism. These include age, genetics, gender, diet, and concurrent medications among others. In this session, we will discuss genetic variations that can affect how patients may respond to certain drugs as well as what kind of adverse effects they might have.

These factors are very important in personalizing drug therapy and making sure that this treatment comes out according to your treatment outcome. Clinical Implications: Drug metabolism goes beyond efficacy to include issues of safety; drug-drug interaction alterations of metabolic pathways leading to increased toxicity or decreased effectiveness of therapy.

As a practical exercise, case studies will be presented to demonstrate and highlight the impact on drug metabolism and the necessity of monitoring dosage.

Innovative Approaches in Drug Development: It will also reflect the most current developments on the optimization of the metabolism that drug development was focusing on. This encompasses the area of in vitro and in vivo studies with regard to predicting human metabolism as well as newer technologies used to predict drug interactions early in the development process.

By the end of this session, an attendee would have a well-rounded understanding of the important role played by drug metabolism in pharmacotherapy.

Learn how to increase your knowledge in metabolic processes and their implications for the patient, thereby bringing about better therapeutic strategies.