The exploitation of Nano scale properties for the optimization of therapeutic efficiency with improved clinical outcomes makes pharmaceutical nanotechnology a frontier in drug development and delivery. In this session, principles of pharmaceutical nanotechnology, Nano medicine, challenges, and opportunities towards nanoparticle formulation and drug delivery systems shall be discussed. Nanotechnology is a manipulation of matter on the nanometer scale, meaning between 1 to 100 nanometers under which the material will be found to have a different physical and chemical characteristic than in larger forms.
This unique characteristic improves or enhances solubility, stability, and bioavailability of pharmaceuticals, especially for poorly soluble drugs in water. Formulation scientists can employ nanotechnology to innovate drug delivery systems that will maximize the therapeutic effect of given drugs.Nanomedicine is an application area of nanotechnology, where the diagnosis or treatment or prevention of disease is done using nanoparticles.
This involves designing of nanoparticles that can recognize and target specific cells or tissues and increase precision and efficacy in drug delivery. Concentration of drugs at the site of action directly benefits therapy in cancerous diseases and chronic diseases because the possibility of off-target side effects is avoided. Among them, most nanoparticle types under investigation as therapeutic drug delivery platforms are liposomes, dendrimers, polymeric nanoparticles, and metal nanoparticles.
Liposomes are the biocompatible vesicles which encapsulate drugs inside them for better stability and controlled release. Polymeric nanoparticles can be prepared in such a way that they can respond to their environment, like pH or temperature, by some changes that allow the appropriate drug delivery at specific conditions in the body.
This implies careful tuning of parameters of designing nanoparticles with respect to particle size, surface charge, composition, and anything else that would affect delivery as a drug and compatibility within biological systems. Regulatory considerations also play a very essential role because products in Nano medicine need to be tested for their safety and efficacy through series of preclinical and clinical trials.
Despite the high potential, many challenges have yet to be addressed in pharmaceutical nanotechnology. Notably, significant hurdles remain in the areas of toxicology and biocompatibility, as well as the possibility of high-volume production and potential for scaling nanoparticle synthesis processes. The whole domain of nanotechnology as related to product development might be subject to variations in public perception, regulatory framework.
Explore with the participants during this session how pharmaceutical nanotechnology could change the future, looking into the same applications but with the emphasis on drug delivery and advancements in the areas of Nano medicine.
This session will emphasize new generation regulatory considerations for the future directions of nanotechnology to improve outcomes in therapy. The information learned on the principles and applications of nanotechnology will enable healthcare professionals to appreciate the role that nanotechnology plays in advancing modern medicine.