Pharma, Pharmaceutics and Biotechnology Conference

Bio-pharmaceutics is the science studying the influence exerted by the pharmacokinetics or in other words by physical and chemical characteristics of drugs, including biologics, upon their absorption, distribution, metabolism, and excretion in the organism. Biologic drugs represent a fast-growing area of therapeutic development with a special tendency towards infectious diseases treatment. The drugs belong to the class of vaccines, monoclonal antibodies, and gene therapies directed against pathogens or intended to improve immune effects of the body upon pathogens.

Biologics are normally much larger, more complex molecular entities that encompass not only proteins, peptides, but also nucleic acids. The development of such drugs involves a specialized set of techniques for their formulation, stability, and delivery, which is quite different from the traditional small-molecule drugs.

For example, a couple of monoclonal antibodies already proven to be effective in neutralizing the specific virus like SARS-CoV-2 need to be designed so that no structural and functional changes occur during administration to patients. Bio-pharmaceutics optimizes such factors so the biologics reach the target with maximum efficacy and minimal side effects.

Vaccines are the second major category of biologics, which prevent infections prior to starting them and alter the course of battles in infectious diseases. Again, bio-pharmaceutics will play a fundamentally important role in developing vaccines, which will range from antigen delivery optimization to time stability and effectiveness of vaccines.

Technologies like mRNA vaccines introduced revolutionized the area through speedy vaccine production with high efficacy rates, such as those that occurred recently during the COVID-19 pandemic. Others advanced therapies that fall in this category include biologic drugs consisting of gene therapy that has the potential to cure genetic disorders that otherwise predispose humans to extreme infections.

Lastly, bio therapeutics are also being researched with the aim of influencing the immune system, either by amplifying it in order to combat infections or dampen an overactive response that causes inflammatory damage.

This session will run the gamut of bio-pharmaceutics in biologic drug development, how it formulates and optimizes these drugs to deliver them in the treatment of infectious disease.

Attendees will hear about the latest advances from monoclonal antibodies through to vaccines and challenges in ensuring their effectiveness in real-world clinical settings.